TROPERO – Ivermectin 1% p/v
Antyparasite solution of
Ivermectin to 1% p/v, endectocide and antiscabies injectable for
bovine and porcine.
..................................... 1 g
Formulation agents csp.,
............... 100 ml
is a formulation whose active ingredient is ivermectin to a 1%
concentration p/v and of persistent action for the control of bovine
and porcine parasytes of most economical impact within cattle
It increases the neuronal
inhibition action to the level of the ventral nervous ring of
parasites which is possible due to the gama-aminobutyric acid (GABA),
in these terms ivermectine is defined as agonist of the GABA with
its GABAergic action, mainly to the level of clhoryde ducts,
stimulating the presinaptic elimination of this neurotransmisor.
Due to an increase in linking to the post sinaptic receptors,
chloryde duct is open increasing the intracellular conduction of the
neurotransmisor hyperpollarizying it, which produces a flaccid
paralysis thus eliminating the parasite.
In nematodes the interference of
nervous impulses takes place between nervous cells whereas in
artropodes this takes place between nervous and muscular cells.
Secondary there exist evidences of the activity of this molecule (macrocyclic
lactone ) linking also to another neurotransmisor, which is the
In bovine: Gastrointestinal
parasites: Bunostomum phlebotomum (adjults L3 and L4)
Cooperia oncophora (adults and L4)
Cooperia pectinata (adults and L4)
Cooperia spp (adults and L3)
Haemonchus placei (adults L3 and
Mecistocirrus digitatus (adults)
Nematodirus helvetianus (adults)
Nematodirus spathiger (adults)
Oesophagostomum radiatum (adults,
L3 and L4)
Ostertagia lyrata (adults and L4)
Ostertagia ostertagi (adults, L3
and L4 including inhibited larvae)
Strongyloides papillosus (adults)
Trichostrongylus axei (adjults and
(adults and L4)
Toxocara vitulorum (adults)
Dictyocaulus viviparus (adults, L4 and inhibited larvae)
produced by: Psoroptes communis var. Bovis, Sarcoptes scabiei var
bovis, Chorioptes bovis.
Haematopinus eurysternus, Linognatus vituli, Solenopotes capillatus.
Myasis. Ura: Dermatobia
Other: Hypoderma bovi, Hypoderma
Navel myasis and castration,
chewing lice, indicated in the control of Bovicola bovis (adults),
Thelazzia spp (adults), Chrysomya bezziana.
Ascaris suum (adults and L4)
Hyostrongylus rubidus (adults and
Oesophagostomum spp. (adults and
Strongyloides ransomi (adults)
Trichuris suis (adults)
Pulmonary parasites :
Metastrongylus spp (adults)
Stephanurus dentatus (adults
prduced by Sarcoptes scabiei var.
DOSE AND WAYS OF ADMINISTRATION
Bovine: 1 ml by each 50 kg live
weight (equivalent of 200 mcg ivermectine by kg l/w.
Do apply by subcutaneous tract in
the neck muscles in front or behind the shoulder ham, using sterile
needle and equipment.
Dosage table in bovine:
Upto 50 Kg................ 1
51 – 100 kg................ 2
101- 150 kg................ 3
l5l - 200 kg................
201 - 250 kg................ 5
251 - 300 kg................ 6
301 - 350 kg................ 7
351 - 400 kg................ 8
401 - 450 kg................ 9
451 - 500 kg................ 10
501 - 550 kg................ 11
551 - 600 kg................ 12
For the treatment and control of
internal parasites in bovine it is recommended to develop an
strategic plan with veterinary advise and consideration should be
given to the category of the animals as well as type and age of the
pastures and previous experiences of the ground with defiant
parasites and also to the actual environment conditions.
It is also recommended to make
periodic coproparasitologic controls by counting h.p.g. of a group
with accurate identification and by doing simultaneous weights.
For the control of lice it is
recommended to repeat the treament after 3 weeks.
Porcine: 1 ml each 33 kg live
weight (equivalent to 300 mcg/kg l/w) by subcutaneous tract over the
lax skin behind the ear or in the groin (internal part of the
muscle) using sterily syringes 12/6 and according to the following
16 kg.........0,5 ml
33 kg........ 1 ml
66 kg ....... 2 ml
100 kg...... 3 ml
133 kg .... 4 ml
166 kg .... 5 ml
200 kg .... 6 ml
For more than 200 kg live weight
apply 1 ml each 33 kg l/w.
In hogs: recommendations of use:
Sucking pigs: at one week of life
and at the unweaning
Female puppy pigs: 1st
birth: 7 to 14 days before service and from 7 to 14 days before
Female pigs: 7 to 14 days before
Colts: at least twice a year.
Castrated sheeps: when entering
the ground that is to say when fatenning starts.
DURATION OF TREATMENT AND
INTERVAL BETWEEN DOSES
Depending on the categories and
the parasitological risk and/or according to the veterinary
Prevention of myasis: at navel:
apply 1 dose in the first 24 hours after birth.
For castration: simultaneously
with this practice.
Recommendation : in both domestic
species and for the control of suck-biting mice, it is recommended
to repeat treatment with an interval of 17-21 days.
RESTRICTIONS OF USE
In bovine: Do no send the meat
from treated animals for human consumption till 35 days after last
application of the product. Do not administer to producing milk
animals nor even during 28 days previous to the birth.
In porcine do not slaughter
treated hogs till 18 days from last treatment.
In greater doses of 10 ml it is
recommended to divide it and apply in two different points.
Do not apply by other tract than
the subcutaenous one.
If it happens to be accidentally
applied by endovenous tract, then there could be trembling,
seizures and coma. A psymptomatic treatment should be prescribed.
There is no specific antidote.
Wash your hands after being used.
Do not eat, drink or smoke during its handling.
Use steryle material and follow
Store the package in fresh place
and avoid daylight keeping it inside the original package, store the
remains within the original package in the same way.
The package must be eliminated by
incineration or burying it because ivermectin in a free state can
contaminate water streams and also injure fishes and another acuatic
Do avoid contact with eyes but if
this is produced, wash with abundant water and consult the
Intoxication National Centre T.E.
Storage: keep in original package
between 4 and 30 Centigrade avoiding daylight.
NET CONTENTS 25, 50, 100, 250 ND 500