Sedative neuroleptic –
preanesthesic injectable – Great and small animals
Sedative , neuroleptic.
Indicated for behavior control : to make differente
operations or surgical/diagnostic procedures (X-rays, treatments,
transportation). Indicated for sedating excited or aggressive
Associated to local anesthesia,
gelding or castrations, removal of cutaneous tumours, ocular surgery
and whirling of great animals. Preanesthesic.
Acepromazine is a sedative that
can be used alone or in combination with anesthesics used for the
induction and keeping, increasing the effect of same.
DOSAGE AND ADMINISTRATION:
Canine: 0,55 to 1,1 mg/kg IV, IM
or SC (1cm3 each 5/10 kg). Dose can be repeated each 8 to 12 hours.
Equine and Bovine: 5mg/100kg IV,
(1 cm3 each 200 kg)
Ovine and Goats: 0,05 to 0,1 mg/kg
Porcine: For sedation: 0,03 to 0,1
Preanesthesic: 0,1 to 0,2 mg/kg
IV, IM or SC
Do not administer more than a
total of 15 mg
Rabbits: For sedation: 1 mg/kg IM.
The effect will start 10 minutes after the application and will last
for 1 to 2 hours.
The use of acepromazine is rather contraindicated in patients in
hypovolemic state or in shock. The simultaneous administration of
one fenotiazine with propanolol can increase the level in blood of
The administration of epinephrine
is contraindicated if fenotiazine derivates are used. Nevertheless
norepinefrine can be used without risk of increasing hypotensor
arterial effects of fenotiazines.
Calculate correctly the weight of
the animal so as to obtain an accurate dosage.
The use of acepromazine will
diminish the dose of the general anesthesic to be administered
because it increases the effect of same.
The hypotensor effect should be
considered. The same applies to the cardiovascular collapse
secondary to bradycardia and hypotension.
Canines are more sensitive to
these effects than other species.
In geriatric patients small doses
were associated with a prolongued effect of the drug.
Canine, giant races and boxers
are extremely sensitive to the drug, by which it should be
cautiously used and at the lowest possible dose. It is advisable to
combine acepromazine with atropine for avoiding the bradicardysing
effects of the first one.
Lower doses should be used when
applied to animals with hepatic problems, cardiac or weak patients.
Acepromazine does not have
analgesic effect therefore a proper analgesic will be used for the
In great male animals it causes
penus protrusion. In colts it should be catiously used due to
injuries which may appear, giving inflammation and even permanent
paralysis of the penus muscle retractor.
Intravenous administration must be
It should not be administered by
The injection by intramuscular
tract can produce transitory pain in the point of injection.
The product is not toxic if it us
used according to the indicated dose.
Generally overdosage can be
controlled with syntomatic treatment.
Hypotension should not be treated
with epinephrine, but with fenilpinefrine or norepinefrine.
Seizures can be controlled with
barbiturics or diazepam.
Suggested antagonist for the
depressing effects of the Central Nervous System produced by
acepromazine is doxapram.
RESTRICTIONS OF USE:
Do not slaughter animals for human
consumption till 24 hours after last treatment. Milk from the first
12 hours after treatment will be stowed away.
Do no administer to saddle horses
during four days previous to the competence.
Net conteins: 50 ml.