PLEACEFULLY  Injectable solution

 

Sedative  neuroleptic preanesthesic injectable Great and small animals

 

FORMULA

Acepromazine maleate........   1,000 g

Excipients c.s.p.............................................   100,00 ml

 

INDICATIONS:  Sedative , neuroleptic. Indicated for behavior control : to make differente operations or surgical/diagnostic procedures (X-rays, treatments, transportation). Indicated for sedating excited or aggressive animals.

Associated to local anesthesia, gelding or castrations, removal of cutaneous tumours, ocular surgery and whirling of great animals. Preanesthesic.

Acepromazine is a  sedative that can be used alone or in combination with anesthesics used for the induction  and keeping, increasing the effect of same.

 

DOSAGE AND ADMINISTRATION:

Canine: 0,55 to 1,1 mg/kg IV, IM or SC (1cm3 each 5/10 kg). Dose can be repeated each 8 to 12 hours.

Equine and Bovine: 5mg/100kg IV, (1 cm3 each 200 kg)

Ovine and Goats: 0,05 to 0,1 mg/kg IM

Porcine: For sedation: 0,03 to 0,1 mg/kg IV

Preanesthesic: 0,1 to 0,2 mg/kg IV, IM or SC

Do not administer more than a total of 15 mg

Rabbits: For sedation: 1 mg/kg IM. The effect will start 10 minutes after the application and will last for 1 to 2 hours.

 

CONTRAINDICATIONS: The use of acepromazine is rather contraindicated in patients in hypovolemic state or in shock. The simultaneous administration of one fenotiazine with propanolol can increase the level in blood of both drugs.

The administration of epinephrine is contraindicated  if fenotiazine derivates are used. Nevertheless norepinefrine can be used without risk of increasing hypotensor arterial effects of fenotiazines.

 

CAUTIONS: Calculate correctly the weight of the animal so as to obtain an accurate dosage.

The use of acepromazine will diminish the dose of the general anesthesic to be administered because it increases the effect of same.

The hypotensor effect should be considered. The same applies to the cardiovascular collapse secondary to  bradycardia and hypotension.

Canines are more sensitive to these effects than other species.

In geriatric patients small doses were associated with a prolongued effect of the drug.

 Canine, giant races  and boxers are extremely sensitive to the drug, by which it should be cautiously used and at  the lowest possible dose. It is advisable to combine acepromazine with atropine for avoiding the  bradicardysing  effects of the first one.

Lower doses should be used when applied to animals with hepatic problems, cardiac or weak patients.

Acepromazine does not have analgesic effect therefore a proper analgesic will be used for the pain control.

In great male animals it causes penus protrusion. In colts it should be catiously used due to injuries which may appear, giving inflammation and even permanent paralysis of the penus muscle retractor.

Intravenous administration must be slow.

It should not be administered  by intraarterial tract.

The injection by intramuscular tract can produce transitory pain in the point of injection.

The product is not toxic if it us used according to the indicated dose.

Generally overdosage can be controlled with syntomatic treatment.

Hypotension should not be treated with epinephrine,  but with fenilpinefrine or norepinefrine.

Seizures can be controlled with barbiturics or diazepam.

Suggested antagonist for the depressing effects of the Central Nervous System produced by acepromazine is doxapram.

 

RESTRICTIONS OF USE:

Do not slaughter animals for human consumption till 24 hours after last treatment. Milk from the first 12 hours after treatment will be stowed away.

Do no administer to saddle horses during four days previous to the competence.

Net conteins: 50 ml.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Laboratorios Vabriela - Sívori 5011 – Munro – Buenos Aires  CP 1605 – Argentina
Teléfono (54 – 11) 47620045)