Acepromazine is a neuroleptic
agent pertaining to the fenotiazine group. It has a sedation effect
by depression of the cerebral stem and cerebral cortex connections.
After being medicated, animals
show a decrease in their spontaneous motor activity, a diminishing
of aggresivity, excitation and anxiety.
It increases the effect of
barbiturics when administered as preanesthetic, which allows a
reduction of those and a longer effect of anesthesia.
Besides, waking up is easily done.
The effects of medication are observed between 15 and 30 minutes
It facilitates handling of the
animal in clinical-surgical procedures and diagnose. It is indicated
to sedate excited or aggressive animals, to make X-rays,
treatments and transportation. Anesthetic premedication.
DOSE AND ADMINISTRATION:
It is directly administered inside the mouth of the animal or
dissolved in water or milk.
Canines: 0,55 to 2,2 mg/kg orally,
that is, 1-4 drops/kg. If it is necessary, dose may be repeated
after 6 to 8 hours.
Felines: 1,1 to 2,2 mg/kg orally,
that is 2-4 drops/kg. If it is necessary, dose can be repeated every
8 to 12 hours.
the use of acepromaxine is relatively contraindicated in patients in
hypovolemic state or in shock. The same applies to patients with
tetanus or intoxication produced by stricnine, due to the effects
over extrapyramidal system.
The simultaneous administration of
fenotiazine with propanolol can increase the level in blood of both
The administration of epinephrine
is contraindicated as far as fenotiazine derivates are used.
Nevertheless, norepinefrine can be used without risk of increasing
the hypotensor arterial effects of fenotiazines.
The use of cepromazine will lower the dose of general anesthesic to
be administered because it increases the effect of same.
The hypotensor effect should be
considered. The same applies to the cardiovascular collapse
secondary to bradycardia and hypotension. Canine are more sensitive
to these effects than other species.
In geriatric patients small doses
were associated with a prolongued effect of the drug. Giant races
and boxers are extremely sensitive to the drug, by which it should
be cautiously used and in the lowest possible dose. It is advisable
to combine acepromazine with atropine so as to avoid the
bradicardysing effects of the first one.
Lower doses should be used when
applied to animals with hepatic problems, cardiac or weak patients.
Acepromazine does not have analgesic effect therefore a proper
analgesic will be used for the pain control.
Suggested dose and warnings are in
all cases subject to the consideration of the veterinary physician.
Be sure that storage conditions are adequate .
Product is not toxic if it is used
according to indicated dose.
Generally overdosage can be
controlled with symptomatic treatment.
Hypotension should not be treated
with epinephrine, but with fenilpinefrine or norepinefrine.
Seizures can be controlled with
barbiturics or diazepam.
Suggested antagonist for the
depressing effects of the Central Nervous System produced by
acepromazine is doxapram. In cases of oral massive overdose, this
should be treated by intestinal emptiness, if it is possible.
Net contains: 10ml