Amoxicilline Clavulanic Acid
Amoxicilline 50 mg Clavulanic
Acid 12,5 mg
Amoxicilline 100 g Clavulanic
Acid 25 mg
Amoxicilline 200 mg Clavulanic
Acid 50 mg
Amoxicilline 300 mg Clavulanic
Acid 75 mg
INDICATIONS OF USE:
Treatment of infections caused by microorganisms sensitive to the
active principles, located in digestive, respiratory, urogenital
tract and skin and in soft tissues. Indicated in wounds, abscesses,
dermatitis, cellulitis, superficial and deep pyodermia,
DOSAGE AND WAYS OF
Canine and Feline: 12,5 mg/kg
Repeat each 12 hours.
Those skin and tissue infectious
such as abscesses, cellulitis, wounds, superficial pyodermia,
periodontal infectious should be treated during 5-7 days or even 48
hours after symptoms are remitted.
Deep pyodermias can require
treatment for approximately 21 days.
Urinary infections need a
treatment period of 14 days
If no improvement is observed
within the first 72 hours, diagnose should be reviewed.
Clavulanic acid is an inhibitor of
the enzymes produced by bacteria (beta-lactamases). It irreversibly
joints to the enzymes avoiding hydrolysis in the amoxicilline
betalactamic ring . When the clavulanic acid joints to the enzyme, a
chemical complex is formed which inactivates the betalactamase.
Amoxicilline is a beta lactamic
antibiotic which acts destroying the wall of the bacterial cells
because it joints to a variety of proteins responsible for the
synthesis of the mentioned wall. The interference with such proteins
produces death and lysis of the bacterias. The joint is produced
with specific objectives of the internal surface of the bacterial
cellular membrane, the PBPs, enzymes (transpeptydases,
carboxypeptidases and endopeptydases) involved in terminal stages of
the bacterial wall connection and in the modification of the
mentioned wall during the cellular division. As a result of the
union, enzymes are inactivated. Inactivation can cause direct
cellular death, with lysis or activation of autolytic enzymes.
The administration to
hypersensitive animals to the active principle
The administration to animals with
septicemia or in shock stage
Horses and rabbits: this
medication is generally contraindicated in these species due to a
potential disturbance of the normal gastrointestinal microflora.
Treatment should not exceed 30
In some cans it can produce
vomits. In these cases it is convenient to feed
the animal previously, thus
diminishing the stomachal irritation.
In some animals it can produce
Cases containing 1, 2, 15 to 30
blisters. Enclosed prospect..
It should be kept between 4 and
30º Centigrade, avoiding direct daylight, in a dry and hygienic
place within its original package.